Lifestyle

New tool facilitates inclusion of people of diverse ancestry in large genetics studies

Genome-wide association studies (GWAS) have typically excluded diverse and minority individuals in the search for gene variants that confer risk of disease. Researchers at Massachusetts General Hospital (MGH), the Broad Institute of MIT and Harvard, and other institutions around the world have now developed a free-access software package called Tractor that increases the discovery power […]

Lifestyle

Research identifies frequent genetic causes of cerebral palsy

Researchers have discovered a strong link between genetic changes known to cause neurodevelopmental disabilities and cerebral palsy. Cerebral palsy affects movement and posture and often co-occurs with other neurodevelopmental disorders, including intellectual disability, epilepsy and autism spectrum disorder. Individual cases of cerebral palsy are often attributed to birth asphyxia, although recent studies indicate that asphyxia […]

Lifestyle

Researchers identify why CAR T therapy may fail in some lymphoma patients

Chimeric antigen receptor T-cell therapy, or CAR T, has been a breakthrough in the treatment of blood cancers such as acute lymphoblastic leukemia and diffuse large B-cell lymphoma. Clinical studies have shown overall response rates of more than 80% with an ongoing response of nearly 40% more than two years after therapy. However, the cellular […]

Lifestyle

Decision-support tool could reduce unnecessary antibiotic prescriptions for child diarrhea

A decision-support tool that could be accessed via mobile devices may help clinicians in lower-resource settings avoid unnecessary antibiotic prescriptions for children with diarrhea, a study published today in eLife shows. The preliminary findings suggest that incorporating real-time environmental, epidemiologic, and clinical data into an easy-to-access, electronic tool could help clinicians appropriately treat children with […]

Lifestyle

Study shows opioid prescriptions remained elevated two years after critical care

Nearly 11 percent of people admitted to an intensive care unit in Sweden between 2010 and 2018 received opioid prescriptions on a regular basis for at least six months and up to two years after discharge. That is according to a study by researchers at Karolinska Institutet published in Critical Care Medicine. The findings suggest […]

Lifestyle

Automated imaging detects and tracks brain protein involved in Alzheimer’s disease

Amyloid-beta and tau are the two key abnormal protein deposits that accumulate in the brain during the development of Alzheimer’s disease, and detecting their buildup at an early stage may allow clinicians to intervene before the condition has a chance to take hold. A team led by investigators at Massachusetts General Hospital (MGH) has now […]

Lifestyle

Study says doctors should discuss hypoglycemia more often with patients who have diabetes

Johns Hopkins Medicine researchers recently found that although primary care physicians should discuss the problems of hypoglycemia, or low blood sugar, during each visit with patients who have diabetes and take high-risk medications such as insulin, the topic was only talked about in a quarter of those visits. Hypoglycemia is the most common serious side […]